Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.

@article{Chang2009BaseER,
  title={Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.},
  author={Jeffrey S. Chang and Margaret R. Wrensch and Helen M. Hansen and Jennette D. Sison and Melinda C Aldrich and Charles Patrick Quesenberry and Michael F. Seldin and Karl T. Kelsey and John K. Wiencke},
  journal={Carcinogenesis},
  year={2009},
  volume={30 1},
  pages={78-87}
}
Base excision repair (BER) is the primary DNA damage repair mechanism for repairing small base lesions resulting from oxidation and alkylation damage. This study examines the association between 24 single-nucleotide polymorphisms (SNPs) belonging to five BER genes (XRCC1, APEX1, PARP1, MUTYH and OGG1) and lung cancer among Latinos (113 cases and 299 controls) and African-Americans (255 cases and 280 controls). The goal was to evaluate the differences in genetic contribution to lung cancer risk… CONTINUE READING

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