Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.

  title={Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.},
  author={Bevin P. Engelward and Geert Weeda and Michael D. Wyatt and Jos{\'e} L.M Broekhof and Jan de Wit and I. Donker and James M. Allan and B. H. Gold and Jan H. J. Hoeijmakers and Leona D. Samson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 24},
3-methyladenine (3MeA) DNA glycosylases remove 3MeAs from alkylated DNA to initiate the base excision repair pathway. Here we report the generation of mice deficient in the 3MeA DNA glycosylase encoded by the Aag (Mpg) gene. Alkyladenine DNA glycosylase turns out to be the major DNA glycosylase not only for the cytotoxic 3MeA DNA lesion, but also for the mutagenic 1,N6-ethenoadenine (epsilonA) and hypoxanthine lesions. Aag appears to be the only 3MeA and hypoxanthine DNA glycosylase in liver… CONTINUE READING


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