Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens.

@article{Cabelof2003BaseER,
  title={Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens.},
  author={Diane C. Cabelof and Zhongmao Guo and Julian J. Raffoul and Robert William Sobol and Samuel H. Wilson and Arlan Richardson and Ahmad Heydari},
  journal={Cancer research},
  year={2003},
  volume={63 18},
  pages={5799-807}
}
The base excision repair pathway (BER) is believed to maintain genomic integrity by repairing DNA damage arising spontaneously or induced by oxidizing and alkylating agents. To establish the role of DNA polymerase beta (beta-pol) in BER and beta-pol-dependent BER in maintaining genomic stability, we have measured the impact of a gene-targeted disruption in the beta-pol gene on DNA repair capacity and on in vivo sensitivity to carcinogens. We have extensively phenotyped the DNA beta-pol… CONTINUE READING

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