Base excision repair and its role in maintaining genome stability.

  title={Base excision repair and its role in maintaining genome stability.},
  author={Joke Baute and Anne Depicker},
  journal={Critical reviews in biochemistry and molecular biology},
  volume={43 4},
For all living organisms, genome stability is important, but is also under constant threat because various environmental and endogenous damaging agents can modify the structural properties of DNA bases. As a defense, organisms have developed different DNA repair pathways. Base excision repair (BER) is the predominant pathway for coping with a broad range of small lesions resulting from oxidation, alkylation, and deamination, which modify individual bases without large effect on the double helix… CONTINUE READING

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