Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome

@article{Yu2012BaseResolutionAO,
  title={Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome},
  author={Miao Yu and Gary Chung Hon and Keith E. Szulwach and Chun-Xiao Song and Liang Zhang and Audrey Kim and Xuekun Li and Qing Dai and Yin Shen and Beomseok Park and Jung-Hyun Min and Peng Jin and Bing Ren and Chuan He},
  journal={Cell},
  year={2012},
  volume={149},
  pages={1368-1380}
}
The study of 5-hydroxylmethylcytosines (5hmC) has been hampered by the lack of a method to map it at single-base resolution on a genome-wide scale. Affinity purification-based methods cannot precisely locate 5hmC nor accurately determine its relative abundance at each modified site. We here present a genome-wide approach, Tet-assisted bisulfite sequencing (TAB-Seq), that when combined with traditional bisulfite sequencing can be used for mapping 5hmC at base resolution and quantifying the… CONTINUE READING
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