Base Metal Catalysis in Directed C( sp 3 )−H Functionalisation

  title={Base Metal Catalysis in Directed C(
 )−H Functionalisation},
  author={Sahra St John‐Campbell and James A. Bull},
  journal={Advanced Synthesis \& Catalysis},
14 Citations
Switchable, Reagent-Controlled C(sp3)-H Selective Iodination and Acetoxylation of 8-Methylquinolines.
An efficient Pd-catalyzed C(sp3)-H selective iodination of 8-methylquinolines is reported herein for the first time and offers a facile access to various C8-substituted quinolines.
Copper Mediated C(sp2)–H Sulfonylation of Aldehydes using a Catalytic Transient Imine Directing Group
The copper mediated β–C(sp2)–H sulfonylation of benzaldehydes with sulfinate salts is accomplished using β-alanine as a catalytic transient directing group. A broad range of sulfonylated
Remote C(sp3)–H functionalization via catalytic cyclometallation: beyond five-membered ring metallacycle intermediates
Despite impressive recent momentum gained in C(sp3)–H activation, achieving high regioselectivity in molecules containing different C–H bonds with similar high energy without abusing tailored
Mn- and Co-Catalyzed Aminocyclizations of Unsaturated Hydrazones Providing a Broad Range of Functionalized Pyrazolines
Cobalt catalysis for the first time paves the way for the selective formation of pyrazoline aldehydes and various functional groups including hydroperoxide, thiol derivatives, iodide, and bicyclopentane may be introduced via manganese-catalyzed ring-forming aminofunctionalization.
Mechanism of 8-Aminoquinoline-Directed Ni-Catalyzed C(sp3)–H Functionalization: Paramagnetic Ni(II) Species and the Deleterious Effect of Carbonate as a Base
Studies into the mechanism of 8-aminoquinoline-directed nickel-catalyzed C(sp3)–H arylation with iodoarenes are described, in an attempt to determine the catalyst resting state and optimize catalytic


Copper‐Catalyzed Site‐Selective Intramolecular Amidation of Unactivated C(sp3)—H Bonds.
The reaction requires a tertiary α-carbon atom since N-quinoline-protected propane and 2-methylpropanamide as well as cyclohexane and cyclopentanecarboxamide do not give the desired products.
Recent advances and prospects in nickel-catalyzed C–H activation
Nickel-catalyzed C–H activation has become a predominant and ubiquitous research area in organic chemistry.
Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited
In 2007 the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable assembled a list of key green chemistry research areas to both identify transformations that would benefit from
Cobalt-catalyzed C–H activation: recent progress in heterocyclic chemistry
Cobalt-catalyzed C–H activation has gone through some major advancements in the past couple of decades. These reactions have proven to be highly efficient, selective, and atom-economical
A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis
As companies grow ever more mindful of the sustainability aspects of their products and supply chains, an increasing focus on the environmental impact of pharmaceutical manufacture spurs innovation
Combining transition metals and transient directing groups for C–H functionalizations
In the domain of synthetic chemistry, C–H bond activation has always remained in the spotlight for researchers over the last few decades. Although different strategies have been employed to