Base-Free Conditions for Rhodium-Catalyzed Asymmetric Arylation To Produce Stereochemically Labile α-Aryl Ketones.

@article{Dou2016BaseFreeCF,
  title={Base-Free Conditions for Rhodium-Catalyzed Asymmetric Arylation To Produce Stereochemically Labile α-Aryl Ketones.},
  author={Xiaowei Dou and Yixin Lu and Tamio Hayashi},
  journal={Angewandte Chemie},
  year={2016},
  volume={55 23},
  pages={
          6739-43
        }
}
The asymmetric arylation of 2,2-dialkyl cyclopent-4-ene-1,3-diones with aryl boronic acids was found to be efficiently catalyzed by a chiral diene-rhodium μ-chloro dimer, [{RhCl((R)-diene*)}2 ], in the absence of bases in toluene/H2 O to give 2,2-dialkyl 4-aryl cyclopentane-1,3-diones in high yields with high enantioselectivity. Such compounds can not be… CONTINUE READING