Base Composition Skews, Replication Orientation, and Gene Orientation in 12 Prokaryote Genomes

@article{McLean1998BaseCS,
  title={Base Composition Skews, Replication Orientation, and Gene Orientation in 12 Prokaryote Genomes},
  author={M. J. McLean and K. H. Wolfe and K. Devine},
  journal={Journal of Molecular Evolution},
  year={1998},
  volume={47},
  pages={691-696}
}
Abstract. Variation in GC content, GC skew and AT skew along genomic regions was examined at third codon positions in completely sequenced prokaryotes. Eight out of nine eubacteria studied show GC and AT skews that change sign at the origin of replication. The leading strand in DNA replication is G-T rich at codon position 3 in six eubacteria, but C-T rich in two Mycoplasma species. In M. genitalium the AT and GC skews are symmetrical around the origin and terminus of replication, whereas its… Expand
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