Basal receptor activation by locally produced glucagon-like peptide-1 contributes to maintaining beta-cell function.

@article{Masur2005BasalRA,
  title={Basal receptor activation by locally produced glucagon-like peptide-1 contributes to maintaining beta-cell function.},
  author={Kai Masur and Elmi C Tibaduiza and Ci Chen and Brooke Ligon and Martin Beinborn},
  journal={Molecular endocrinology},
  year={2005},
  volume={19 5},
  pages={
          1373-82
        }
}
Glucagon-like peptide 1 (GLP-1) is a physiological stimulus of pancreatic beta-cell function. This enteroendocrine hormone is produced by intestinal L cells, and is delivered via the bloodstream to GLP-1 receptors (GLP-1Rs) on pancreatic beta-cells. In addition, there is evidence that beta-cell GLP-1Rs maintain sustained basal activity even in the absence of intestinal peptide, an observation that has raised the question whether these receptors have some degree of ligand-independent function… CONTINUE READING

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