Basal reactive oxygen species determine the susceptibility to apoptosis in cirrhotic hepatocytes.

@article{Raval2006BasalRO,
  title={Basal reactive oxygen species determine the susceptibility to apoptosis in cirrhotic hepatocytes.},
  author={Jay S Raval and Suzanne Lyman and Takashi Nitta and Dagmara Mohuczy and John J. Lemasters and Jae-Sung Kim and Kevin E. Behrns},
  journal={Free radical biology & medicine},
  year={2006},
  volume={41 11},
  pages={1645-54}
}
Hepatocytes from cirrhotic murine livers exhibit increased basal ROS activity and resistance to TGFbeta-induced apoptosis, yet when ROS levels are decreased by antioxidant pretreatment, these cells recover susceptibility to apoptotic stimuli. To further study these redox events, hepatocytes from cirrhotic murine livers were pretreated with various antioxidants prior to TGFbeta treatment and the ROS activity, apoptotic response, and mitochondrial ROS generation were assessed. In addition, normal… CONTINUE READING

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