Basal-prandial versus premixed insulin in patients with type 2 diabetes requiring insulin intensification after basal insulin optimization: A 24-week randomized non-inferiority trial.

@article{Jin2016BasalprandialVP,
  title={Basal-prandial versus premixed insulin in patients with type 2 diabetes requiring insulin intensification after basal insulin optimization: A 24-week randomized non-inferiority trial.},
  author={Sang-Man Jin and Jae Hyeon Kim and Kyung Wan Min and Ji Hyun Lee and Kue Jeong Ahn and Jeong Hyun Park and Hak Chul Jang and Seok Won Park and Kwan Woo Lee and Kyu Chang Won and Young-il Kim and Choon Hee Chung and Tae Sun Park and Jee-Hyun Lee and Moon-Kyu Lee},
  journal={Journal of diabetes},
  year={2016},
  volume={8 3},
  pages={405-13}
}
BACKGROUND The aim of the present 24-week multicentre randomized non-inferiority trial was to compare the efficacy and safety of two insulin intensification strategies in uncontrolled type 2 diabetes despite optimized basal insulin therapy. METHODS Patients with fasting plasma glucose (FPG) <130 mg/dL and HbA1c 7.0%-10.0% while on insulin glargine were randomized to a basal-prandial group (stepwise addition of insulin glulisine) or a premixed insulin group (insulin aspart/insulin aspart… CONTINUE READING

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