Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue.

@article{Drgert2016BasalMA,
  title={Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue.},
  author={Katja Dr{\"a}gert and Indranil Bhattacharya and Michael N. Hall and Rok Humar and Edouard Battegay and Elvira Haas},
  journal={Biochemical and biophysical research communications},
  year={2016},
  volume={473 1},
  pages={317-322}
}
In adipose tissue mTOR complex 2 (mTORC2) contributes to the regulation of glucose/lipid metabolism and inflammatory molecule expression. Both processes display diurnal variations during the course of the day. RICTOR and mSIN1 are unique and essential components of mTORC2, which is activated by growth factors including insulin. To assess whether mTORC2 components display diurnal variations, we analyzed steady state mRNA expression levels of Rictor, mSin1, and mTor in various adipose tissues… CONTINUE READING