Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival

@inproceedings{Weigman2011BasallikeBC,
  title={Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival},
  author={Victor J. Weigman and Hann-Hsiang Chao and Andrey A. Shabalin and Xiaping He and Joel S. Parker and Silje H. Nordgard and Tatyana A. Grushko and Dezheng Huo and Chika Nwachukwu and Andrew B. Nobel and Vessela N. Kristensen and Anne-Lise B\orresen-Dale and Olufunmilayo I. Olopade and Charles M. Perou},
  booktitle={Breast Cancer Research and Treatment},
  year={2011}
}
Breast cancer is a heterogeneous disease with known expression-defined tumor subtypes. DNA copy number studies have suggested that tumors within gene expression subtypes share similar DNA Copy number aberrations (CNA) and that CNA can be used to further sub-divide expression classes. To gain further insights into the etiologies of the intrinsic subtypes, we classified tumors according to gene expression subtype and next identified subtype-associated CNA using a novel method called SWITCHdna… CONTINUE READING

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