Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E.

@article{EspinosaHeidmann2004BasalLD,
  title={Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E.},
  author={Diego G. Espinosa-Heidmann and John Sall and Eleut P. Hernandez and Scott W. Cousins},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 1},
  pages={260-6}
}
PURPOSE Dietary fat intake has been proposed as a mechanism of sub-RPE deposit formation. It has been demonstrated recently that sub-RPE deposits develop in 16- to 18-month-old C57BL/6 mice fed a high-fat diet and exposed to blue-green light. Hyperlipidemia also develops in these mice after they consume a high-fat diet. Because hyperlipidemia also develops in young C57BL/6 mice that overexpress APO B100, the major apolipoprotein in LDL cholesterol, this research was conducted to determine… CONTINUE READING
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