Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy.

@article{Capuron2007BasalGH,
  title={Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy.},
  author={Lucile Capuron and Giuseppe Pagnoni and Marina F Demetrashvili and David H. Lawson and Fiona B Fornwalt and Bobbi J. Woolwine and Gregory S. Berns and Charles B. Nemeroff and Andrew H. Miller},
  journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year={2007},
  volume={32 11},
  pages={2384-92}
}
Interferon (IFN)-alpha is a cytokine of the innate immune response that is well known for inducing behavioral alterations and has been used to study effects of cytokines on the nervous system. Limited data, however, are available on the sites of action of IFN-alpha within the brain and their relationship with specific IFN-alpha-induced symptoms. Using a longitudinal design, whole-brain metabolic activity as assessed by fluorine-18-labeled fluorodeoxyglucose uptake and positron emission… CONTINUE READING
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