Basal ganglia group II metabotropic glutamate receptors specific binding in non-human primate model of L-Dopa-induced dyskinesias

@article{Samadi2008BasalGG,
  title={Basal ganglia group II metabotropic glutamate receptors specific binding in non-human primate model of L-Dopa-induced dyskinesias},
  author={Pershia Samadi and Laurent Gr{\'e}goire and Marc Morissette and Fr{\'e}d{\'e}ric Calon and Th{\'e}r{\`e}se Di Paolo},
  journal={Neuropharmacology},
  year={2008},
  volume={54},
  pages={258-268}
}
L-Dopa-induced dyskinesias (LIDs), the disabling abnormal involuntary movements induced by chronic use of L-Dopa, limit the quality of life in Parkinson's disease (PD) patients. Modulation of group II metabotropic glutamate receptors (mGluR2/3) in the basal ganglia, a brain region critically involved in motor control, is considered as an alternative approach in therapy of PD. In this study, receptor binding autoradiography of [3H]LY341495, a mGluR2/3 selective radioligand, was used to… CONTINUE READING
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