Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction.

@article{Takakusaki2003BasalGE,
  title={Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction.},
  author={Kaoru Takakusaki and Tatsuya Habaguchi and J Ohtinata-Sugimoto and Kazuya Saitoh and T. Sakamoto},
  journal={Neuroscience},
  year={2003},
  volume={119 1},
  pages={293-308}
}
The present study is designed to elucidate how basal ganglia afferents from the substantia nigra pars reticulata (SNr) to the mesopontine tegmental area of the brainstem contribute to gait control and muscle-tone regulation. We used unanesthetized and acutely decerebrated cats (n=27) in which the striatum, thalamus and cerebral cortex were removed but the SNr was preserved. Repetitive stimulation (50 Hz, 10-60 microA, for 5-20 s) applied to a mesencephalic locomotor region (MLR), which… CONTINUE READING
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