Basal ganglia dysfunction in OCD: subthalamic neuronal activity correlates with symptoms severity and predicts high-frequency stimulation efficacy

@inproceedings{Welter2011BasalGD,
  title={Basal ganglia dysfunction in OCD: subthalamic neuronal activity correlates with symptoms severity and predicts high-frequency stimulation efficacy},
  author={Marie-Laure Welter and Pierre Burbaud and Sara Fernandez-Vidal and Etienne Bardinet and J{\'e}r{\^o}me Coste and Brigitte Piallat and Michel Borg and St{\'e}phane Besnard and Paul Sauleau and Bertrand Devaux and Bernard Pidoux and P Chaynes and Sophie T{\'e}zenas du Montcel and Amy Bastian and Nicolas Langbour and A Teillant and Wanda Haynes and J{\'e}r{\^o}me Yelnik and Carine Karachi and Luc Mallet},
  booktitle={Translational Psychiatry},
  year={2011}
}
Functional and connectivity changes in corticostriatal systems have been reported in the brains of patients with obsessive–compulsive disorder (OCD); however, the relationship between basal ganglia activity and OCD severity has never been adequately established. We recently showed that deep brain stimulation of the subthalamic nucleus (STN), a central basal ganglia nucleus, improves OCD. Here, single-unit subthalamic neuronal activity was analysed in 12 OCD patients, in relation to the severity… CONTINUE READING