Basal ganglia-cortical structural connectivity in Huntington's disease.

  title={Basal ganglia-cortical structural connectivity in Huntington's disease.},
  author={Marianne J. U. Novak and Kiran K. Seunarine and Clare R Gibbard and Peter McColgan and Bogdan Draganski and Karl Friston and Chris A Clark and Sarah J Tabrizi},
  journal={Human brain mapping},
  volume={36 5},
Huntington's disease is an incurable neurodegenerative disease caused by inheritance of an expanded cytosine-adenine-guanine (CAG) trinucleotide repeat within the Huntingtin gene. Extensive volume loss and altered diffusion metrics in the basal ganglia, cortex and white matter are seen when patients with Huntington's disease (HD) undergo structural imaging, suggesting that changes in basal ganglia-cortical structural connectivity occur. The aims of this study were to characterise altered… CONTINUE READING
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