Basal ganglia N-acetylaspartate correlates with the performance in the procedural task 'Tower of Hanoi' of neuroleptic-naive schizophrenic patients.

@article{Gimnez2003BasalGN,
  title={Basal ganglia N-acetylaspartate correlates with the performance in the procedural task 'Tower of Hanoi' of neuroleptic-naive schizophrenic patients.},
  author={M{\'o}nica Gim{\'e}nez and Carme Junque and Mercedes Rodr{\'i}guez P{\'e}rez and Pere Vendrell and Imma Baeza and Manuel Salamero and Josep Maria Mercader and Miquel Bernardo},
  journal={Neuroscience letters},
  year={2003},
  volume={347 2},
  pages={97-100}
}
We tested the hypothesis that basal ganglia dysfunction may be related to procedural learning impairment in schizophrenia. We determined the N-acetylaspartate/choline (NAA/Cho) ratio in the left striatal area in 11 young first-episode antipsychotic-naive patients and matched controls. Procedural learning was assessed by the four-disk version of the Tower of Hanoi. Analysis of variance showed that the number of moves and the execution time had a significant group effect (P=0.02, P<0.0001… CONTINUE READING