Basal forebrain carbachol injection reduces cortical acetylcholine turnover and disrupts memory.

Abstract

Injection of the cholinergic agonist carbachol into the region of cholinergic cell bodies in the basal forebrain decreases the turnover rate of acetylcholine in the cortex of the rat, as measured by a mass fragmentographic technique. Moreover, this treatment has been found to increase the number of working memory errors committed as measured in the 8-arm… (More)

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