Basal dephosphorylation controls slow gating of L-type Ca2+ channels in human vascular smooth muscle.

@article{Groschner1995BasalDC,
  title={Basal dephosphorylation controls slow gating of L-type Ca2+ channels in human vascular smooth muscle.},
  author={Klaus Groschner and Klaus Schuhmann and Werner Baumgartner and Vassili F. Pastushenko and Hansgeorg Schindler and Christoph Romanin},
  journal={FEBS letters},
  year={1995},
  volume={373 1},
  pages={30-4}
}
The role of cellular phosphatase activity in regulation of smooth muscle L-type Ca2+ channels was investigated using tautomycin, a potent and specific inhibitor of serin/threonin phosphatases type 1 and 2A. Tautomycin (1-100 nM) inhibited Ca2+ channel activity in smooth muscle cells isolated from human umbilical vein. Tautomycin-induced inhibition of Ca2+ channel activity was due to a reduction of channel availability which originated mainly from prolongation of the lifetime of unavailable… CONTINUE READING