Basal cell carcinomas: attack of the hedgehog

  title={Basal cell carcinomas: attack of the hedgehog},
  author={Ervin H. Epstein},
  journal={Nature Reviews Cancer},
Basal cell carcinomas (BCCs) were essentially a molecular 'black box' until some 12 years ago, when identification of a genetic flaw in a rare subset of patients who have a great propensity to develop BCCs pointed to aberrant Hedgehog signalling as the pivotal defect leading to formation of these tumours. This discovery has facilitated a remarkable increase in our understanding of BCC carcinogenesis and has highlighted the carcinogenic role of this developmental pathway when aberrantly… CONTINUE READING
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