Basal body stability and ciliogenesis requires the conserved component Poc1

@inproceedings{Pearson2009BasalBS,
  title={Basal body stability and ciliogenesis requires the conserved component Poc1},
  author={Chad G Pearson and Daniel P.S. Osborn and Thomas H. Giddings and Philip L. Beales and Mark Winey},
  booktitle={The Journal of cell biology},
  year={2009}
}
Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule scaffold that is capable of withstanding microtubule-based forces generated by centrosomes and cilia. We report that the conserved WD40 repeat domain-containing cartwheel protein Poc1 is required for the structural maintenance of centrioles in… CONTINUE READING