Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress.

@article{Antonucci2015BasalAM,
  title={Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress.},
  author={Laura Antonucci and Johan B Fagman and Ju Youn Kim and Jelena Todoric and I. Ya. Gukovsky and Mason R. Mackey and Mark H. Ellisman and Michael Karin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 45},
  pages={E6166-74}
}
Pancreatic acinar cells possess very high protein synthetic rates as they need to produce and secrete large amounts of digestive enzymes. Acinar cell damage and dysfunction cause malnutrition and pancreatitis, and inflammation of the exocrine pancreas that promotes development of pancreatic ductal adenocarcinoma (PDAC), a deadly pancreatic neoplasm. The cellular and molecular mechanisms that maintain acinar cell function and whose dysregulation can lead to tissue damage and chronic pancreatitis… CONTINUE READING