Basal and dexamethasone suppressed salivary cortisol concentrations in a community sample of patients with posttraumatic stress disorder

  title={Basal and dexamethasone suppressed salivary cortisol concentrations in a community sample of patients with posttraumatic stress disorder},
  author={Steven E. Lindley and Eve Carlson and Maryse Beno{\^i}t},
  journal={Biological Psychiatry},

Basal and suppressed salivary cortisol in female Vietnam nurse veterans with and without PTSD

Cortisol and post-traumatic stress disorder in adults

Comparison of basal cortisol levels in adults with current PTSD and in people without psychiatric disorder revealed that studies assessing plasma or serum showed significantly lower levels in people with PTSD than in controls not exposed to trauma.

The role of personality and traumatic events in cortisol levels – Where does PTSD fit in?

Alterations in Stress Reactivity After Long‐Term Treatment with Paroxetine in Women with Posttraumatic Stress Disorder

Assessment of the effect of long‐term treatment with the selective reuptake inhibitor (SSRI), paroxetine, on stress reactivity in patients with PTSD suggests that successful treatment with SSRI in chronic PTSD is associated with a trend for a decrease in baseline diurnal cortisol and with reduced cortisol reactivity to stress.

The role of cortisol in PTSD among women exposed to a trauma-related stressor.

Tobacco usage interacts with postdisaster psychopathology on circadian salivary cortisol.

  • M. OlffM. Meewisse B. Gersons
  • Psychology
    International journal of psychophysiology : official journal of the International Organization of Psychophysiology
  • 2006



Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder.

The data support earlier studies showing that HPA abnormalities in PTSD are different from those seen in depression and suggest that the low-dose dexamethasone suppression test may be a potentially useful tool for differentiating the two syndromes and further exploring differences in their pathophysiology.

Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder.

The data support the hypothesis of an enhanced negative feedback sensitivity of the hypothalamic-pituitary-adrenal axis in PTSD and combat veterans with PTSD suppressed cortisol to a greater extent than did combat veterans without PTSD and normal controls in response to both doses of dexamethasone.

Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder.

The finding that patients with PTSD had a substantially greater number of lymphocyte glucocorticoid receptors than normal comparison subjects is consistent with the authors' previous observations of low 24-hour urinary cortisol excretion in subjects with PTSD.

Low Urinary Cortisol Excretion in Patients with Posttraumatic Stress Disorder

A physiological adaptation of the hypothalamic-pituitary- adrenal axis to chronic stress is suggested in posttraumatic stress disorder (PTSD).

Plasma Testosterone Levels in Patients with Combat-Related Posttraumatic Stress Disorder

The findings of plasma testosterone levels comparable with normal controls in CR-PTSD patients may indicate that the previously described reduction in testosterone levels in normal subjects under stressful conditions may reflect the acute stress response of the HPG axis, in contrast to an adaptation of theHPG axis under chronic psychological stress.

Biology of posttraumatic stress disorder.

  • R. Yehuda
  • Biology, Psychology
    The Journal of clinical psychiatry
  • 2001
Sensitivity of the HPA axis is consistent with the clinical picture of hyperreactivity and hyperresponsiveness in PTSD, and the reduction in cortisol levels results from an enhanced negative feedback by cortisol, which is secondary to an increased sensitivity of glucocorticoid receptors in target tissues.