Basal and Regulatory Promoter Studies of the AKR1C3 Gene in Relation to Prostate Cancer

Abstract

BACKGROUND Human 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5) formally known as aldo-keto reductase 1C3 (AKR1C3) play a major role in the formation and metabolism of androgens. The enzyme is highly expressed in the prostate gland and previous studies indicate that genetic variation in the AKR1C3 gene may influence the prostate volume and risk of… (More)
DOI: 10.3389/fphar.2012.00151

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