• DOI:10.1177/1066896915593802
• Corpus ID: 206650583

Basal Cell Carcinoma and Seborrheic Keratosis

@article{Fusco2015BasalCC,
  title={Basal Cell Carcinoma and Seborrheic Keratosis},
  author={Nicola Fusco and Gianluca Lopez and Umberto Gianelli},
  journal={International Journal of Surgical Pathology},
  year={2015},
  volume={23},
  pages={464 - 464}
}

• N. Fusco, G. Lopez, U. Gianelli
• Published 1 July 2015
• Medicine
• International Journal of Surgical Pathology

Basal cell carcinoma is the most common cutaneous malignancy, accounting for approximately 70% of all nonmelanoma skin cancers. This tumor can occasionally be observed in association with seborrheic keratosis, the most common benign tumor of the epidermis. The clonal relationship between basal cell carcinoma and seborrheic keratosis is still a matter of controversy, and the debate as to whether this exceedingly rare association constitutes a collision tumor or is generated by phenomena of tumor progression continues. Here we illustrate a nodular basal cell carcinoma arising within a focus of seborrheic keratosis in a 57-year-old woman with a skin lesion of the right arm. The double neoplastic population can be clearly appreciated by hematoxylin and eosin (Figure 1). In this case, the superficial spread of one component was limited by the other, while the reticular dermis underneath the seborrheic keratosis was massively infiltrated by the nodular proliferation of transformed basal cells. Our findings are consistent with the notion that the association of seborrheic keratosis and malignant neoplasms is more than purely coincidental.