Basal, but not overload-induced, myonuclear addition is attenuated by NG-nitro-L-arginine methyl ester (L-NAME) administration.

@article{Gordon2007BasalBN,
  title={Basal, but not overload-induced, myonuclear addition is attenuated by NG-nitro-L-arginine methyl ester (L-NAME) administration.},
  author={Scott E. Gordon and Christopher M Westerkamp and Kathleen J Savage and Robert C. Hickner and Sarah C George and Christopher A Fick and Kathleen M. McCormick},
  journal={Canadian journal of physiology and pharmacology},
  year={2007},
  volume={85 6},
  pages={646-51}
}
The purpose of this study was to examine the effect of blocking nitric oxide synthase (NOS) activity via NG-nitro-L-arginine methyl ester (L-NAME) on myonuclear addition in skeletal muscle under basal and overloaded conditions. Female Sprague-Dawley rats (approx. 220 g) were placed into 1 of the following 4 groups (n = 7-9/group): 7-day skeletal muscle overload (O), sham operation (S), skeletal muscle overload with L-NAME treatment (OLN), and sham operation with L-NAME treatment (SLN… CONTINUE READING
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