Barttin activates ClC-K channel function by modulating gating.

  title={Barttin activates ClC-K channel function by modulating gating.},
  author={Martin Fischer and Audrey G H Janssen and Christoph Fahlke},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={21 8},
Barttin is an accessory subunit that modifies protein stability, subcellular distribution, and voltage-dependent gating of ClC-K chloride channels expressed in renal and inner ear epithelia. ClC-K channels are double-barreled channels with two identical protopores that may be opened by individual or common gating processes. Using heterologous expression in mammalian cells and patch-clamp recordings, we studied the effects of barttin on gating of rat ClC-K1 and human ClC-Ka. In the absence of… CONTINUE READING


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