Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host‐directed therapies

@article{Lyle2014BarriersTT,
  title={Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host‐directed therapies},
  author={Ngan H. Lyle and Olga M. Pena and John H. Boyd and Robert E. W. Hancock},
  journal={Annals of the New York Academy of Sciences},
  year={2014},
  volume={1323}
}
Sepsis is a complex clinical syndrome involving both infection and a deleterious host immune response. Antimicrobial agents are key elements of sepsis treatment, yet despite great strides in antimicrobial development in the last decades, sepsis continues to be associated with unacceptably high mortality (∼30%). This is the result, on one hand, of the rise of antimicrobial resistant organisms and, on the other hand, of the dearth of effective host‐directed immune therapies. A major obstacle to… 
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