• DOI:10.1111/nyas.12444
Corpus ID: 5089865

Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host‐directed therapies

@article{Lyle2014BarriersTT,
  title={Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host‐directed therapies},
  author={Ngan H. Lyle and O. Pena and J. Boyd and R. Hancock},
  journal={Annals of the New York Academy of Sciences},
  year={2014},
  volume={1323}
}

• Ngan H. Lyle, O. Pena, +1 author R. Hancock
• Published 2014
• Medicine
• Annals of the New York Academy of Sciences

Sepsis is a complex clinical syndrome involving both infection and a deleterious host immune response. Antimicrobial agents are key elements of sepsis treatment, yet despite great strides in antimicrobial development in the last decades, sepsis continues to be associated with unacceptably high mortality (∼30%). This is the result, on one hand, of the rise of antimicrobial resistant organisms and, on the other hand, of the dearth of effective host‐directed immune therapies. A major obstacle to… Expand

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