Barrierless evolution of structure during the submillisecond refolding reaction of a small protein.


To determine whether a protein folding reaction can occur in the absence of a dominant barrier is crucial for understanding its complexity. Here direct ultrafast kinetic measurements have been used to study the initial submillisecond (sub-ms) folding reaction of the small protein barstar. The cooperativity of the initial folding reaction has been explored… (More)
DOI: 10.1073/pnas.0803193105


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