Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila.

@article{Furukawa2003BarriertoautointegrationFP,
  title={Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila.},
  author={Kazuhiro Furukawa and Shin Sugiyama and Shinichi Osouda and Hidemasa Bono Susumu Goto and Masaki Inagaki and Tsuneyoshi Horigome and Saburo Omata and Maeve McConnell and Paul Anthony Fisher and Yasuyoshi Nishida},
  journal={Journal of cell science},
  year={2003},
  volume={116 Pt 18},
  pages={3811-23}
}
Barrier-to-autointegration factor (BAF) is potentially a DNA-bridging protein, which directly associates with inner nuclear membrane proteins carrying LEM domains. These features point to a key role in regulation of nuclear function and organization, dependent on interactions between the nuclear envelope and chromatin. To understand the functions of BAF in vivo, Drosophila baf null mutants generated by P-element-mediated imprecise excision were analyzed. Homozygous null mutants showed a typical… CONTINUE READING