Barrier-to-autointegration factor-like (BAF-L): a proposed regulator of BAF.

  title={Barrier-to-autointegration factor-like (BAF-L): a proposed regulator of BAF.},
  author={Kathryn E Tifft and Miriam Segura-Totten and Kenneth Ka-Ho Lee and Katherine L. Wilson},
  journal={Experimental cell research},
  volume={312 4},
Barrier-to-autointegration factor (BAF) is an essential chromatin protein conserved in metazoans. BAF has roles in nuclear assembly, chromatin organization, gene expression, and gonad development and is exploited by retroviruses. BAF forms stable dimers that bind nonspecifically to dsDNA and specifically to LEM-domain proteins (e.g., LAP2beta, emerin, MAN1), homeodomain transcription factors, histones, and lamin A. We characterized a protein named BAF-Like (BAF-L) that in humans is 40… CONTINUE READING

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