Barrier-to-autointegration factor is required to segregate and enclose chromosomes within the nuclear envelope and assemble the nuclear lamina.

@article{Margalit2005BarriertoautointegrationFI,
  title={Barrier-to-autointegration factor is required to segregate and enclose chromosomes within the nuclear envelope and assemble the nuclear lamina.},
  author={Ayelet Margalit and Miriam Segura-Totten and Yosef Gruenbaum and Katherine L. Wilson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 9},
  pages={3290-5}
}
Barrier-to-autointegration factor (BAF) binds dsDNA, LEM-domain proteins, and lamins. Caenorhabditis elegans BAF requires Ce-lamin and two LEM-domain proteins (Ce-emerin and Ce-MAN1) to localize during nuclear assembly. It was unknown whether Ce-lamin and LEM proteins, in turn, depend on Ce-BAF (mutually dependent structural roles). RNA interference… CONTINUE READING