Barrier properties of gastrointestinal mucus to nanoparticle transport.

@article{Crater2010BarrierPO,
  title={Barrier properties of gastrointestinal mucus to nanoparticle transport.},
  author={Jason S Crater and Rebecca L Carrier},
  journal={Macromolecular bioscience},
  year={2010},
  volume={10 12},
  pages={
          1473-83
        }
}
Gastrointestinal mucus, a complex network of highly branched glycoproteins and macromolecules, is the first barrier through which orally delivered drug and gene vectors must traverse. The diffusion of such vectors can be restricted by the high adhesivity and viscoelasticity of mucus. In this investigation, the barrier properties of gastrointestinal mucus to particle transport were explored using real-time multiple particle tracking. The influence of surface chemistry on particle transport rates… 

Figures from this paper

Size selectivity of intestinal mucus to diffusing particulates is dependent on surface chemistry and exposure to lipids
TLDR
Results indicate that reduction of particle size may increase particle transport through intestinal mucus barriers, but these effects are strongly dependent on intestinal contents and particle surface chemistry.
Mucus as a barrier to drug delivery – understanding and mimicking the barrier properties.
TLDR
Current knowledge of mucus characteristics and barrier properties, as achieved by state-of-the-art methodologies, is the topic of this MiniReview emphasizing the gastrointestinal mucus and an overall focus on oral drug delivery.
Lipid-based Mucus Penetrating Nanoparticles and their Biophysical Interactions with Pulmonary Mucus Layer.
  • Gokce Alp, Nihal Aydogan
  • Biology, Materials Science
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2020
Modulation of Gastrointestinal Mucus Properties with Ionic Liquids for Drug Delivery
TLDR
The potential for choline‐based ionic liquids to be used as nondestructive mucus‐modulating agents for enabling enhanced oral delivery of macromolecular drugs is demonstrated.
Mucus as a barrier to lipophilic drugs.
Comparing the permeability of human and porcine small intestinal mucus for particle transport studies
TLDR
This work validates the use of porcine small intestinal mucus collected from fully-grown pigs for studying colloidal transport of sub-micron sized particles in mucus under conditions mimicking the adult human small intestinal environment.
Preparation and characterization of mucus-penetrating papain/poly(acrylic acid) nanoparticles for oral drug delivery applications
TLDR
Improved transport rates, reduction in mucus viscosity and the retarded release of hydrophilic macromolecular compounds make proteolytic enzyme functionalized nanoparticles of substantial interest for improved targeted drug delivery at mucosal surfaces.
Food-associated stimuli enhance barrier properties of mucus
TLDR
The motivation for studying these phenomena includes understanding how drug delivery and microbe transport through mucus may change upon food exposure, and how these effects may be exploited to enable more efficient drug delivery or block pathogen transport.
Chemical and physical strategiespromoting nanoparticle permeationthrough intestinal mucus barrier
TLDR
Sulfobetaine NPs were highly efficient NPs in term of their stability, charge density, particle size and importantly their diffusivities through the mucus barrier which was significantly higher as compared with all other tested NPs and related to the ratio of the sulfobetane polymer in the NPs.
...
...

References

SHOWING 1-10 OF 32 REFERENCES
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
TLDR
It is demonstrated that large nanoparticles, if properly coated, can rapidly penetrate physiological human mucus, and they offer the prospect thatLarge nanoparticles can be used for mucosal drug delivery.
Transport of Polymeric Nanoparticle Gene Carriers in Gastric Mucus
TLDR
Improved transport rates, stability in mucus, and ability to transfect cells make PLGA‐DDAB/DNA nanoparticles candidates for mucosal DNA vaccines and gene therapy.
Micro- and macrorheology of mucus.
Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier.
TLDR
To increase the bioavailability of cargo therapeutics, it is important that carrier particles rapidly penetrate mucus to avoid being shed, and for localized drug and gene delivery at mucosal surfaces.
PEGylation of nanoparticles improves their cytoplasmic transport
TLDR
Faster particle transport correlated with a marked decrease in the number of particles that underwent hindered transport, from 79.2% (unmodified) to 48.8% (PEGylated).
Enhanced Viscoelasticity of Human Cystic Fibrotic Sputum Correlates with Increasing Microheterogeneity in Particle Transport*
TLDR
Treatment with recombinant human DNase (Pulmozyme®) reduces macroviscoelastic properties of CF sputum by up to 50% and dramatically narrows the distribution of individual particle diffusion rates but surprisingly does not significantly alter the ensemble-average particle diffusion rate.
The physical properties of biogels and their permeability for macromolecular drugs and colloidal drug carriers.
TLDR
The physicochemical properties of biogels, macromolecular drugs, and colloidal drug carriers that play a major role in transport throughBiogels are reviewed and methods of studying the mobility of macromolescular drugs and colloid drug carriers in and through biogel are addressed.
...
...