Barrier properties of gastrointestinal mucus to nanoparticle transport.

  title={Barrier properties of gastrointestinal mucus to nanoparticle transport.},
  author={Jason S Crater and Rebecca L Carrier},
  journal={Macromolecular bioscience},
  volume={10 12},
Gastrointestinal mucus, a complex network of highly branched glycoproteins and macromolecules, is the first barrier through which orally delivered drug and gene vectors must traverse. The diffusion of such vectors can be restricted by the high adhesivity and viscoelasticity of mucus. In this investigation, the barrier properties of gastrointestinal mucus to particle transport were explored using real-time multiple particle tracking. The influence of surface chemistry on particle transport rates… 

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