Barrier properties of gastrointestinal mucus to nanoparticle transport.

@article{Crater2010BarrierPO,
  title={Barrier properties of gastrointestinal mucus to nanoparticle transport.},
  author={Jason S. Crater and R. Carrier},
  journal={Macromolecular bioscience},
  year={2010},
  volume={10 12},
  pages={
          1473-83
        }
}
  • Jason S. Crater, R. Carrier
  • Published 2010
  • Medicine, Chemistry
  • Macromolecular bioscience
  • Gastrointestinal mucus, a complex network of highly branched glycoproteins and macromolecules, is the first barrier through which orally delivered drug and gene vectors must traverse. The diffusion of such vectors can be restricted by the high adhesivity and viscoelasticity of mucus. In this investigation, the barrier properties of gastrointestinal mucus to particle transport were explored using real-time multiple particle tracking. The influence of surface chemistry on particle transport rates… CONTINUE READING

    Figures and Topics from this paper.

    Mucus as a barrier to lipophilic drugs.
    142
    Food-associated stimuli enhance barrier properties of mucus
    The role of mucus on drug transport and its potential to affect therapeutic outcomes☆
    45

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 32 REFERENCES
    Micro- and macrorheology of mucus.
    607
    PEGylation of nanoparticles improves their cytoplasmic transport
    118