Barrier mechanisms for neurotransmitter monoamines and their precursors at the blood‐brain interface

@article{Hardebo1980BarrierMF,
  title={Barrier mechanisms for neurotransmitter monoamines and their precursors at the blood‐brain interface},
  author={Jan Erik Hardebo and Ch. Owman},
  journal={Annals of Neurology},
  year={1980},
  volume={8}
}
The integrity of the endothelial cell lining of the cerebrovascular bed constitutes a morphological blood‐brain barrier mechanism to neurotransmitter monoamines. Circulating monoamines are prevented from entering the brain primarily at the luminal membrane of the endothelial lining. The small percentage of amines that may pass this membrane is deaminated within the endothelial cells and pericytes of brain microvessels (capillaries, venules, and small veins) and, in the case of large parenchymal… 

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During the past decade methods to isolate and study microvessels from brain, and to grow the endothelial cells in tissue culture permit a more detailed characterization of the specialized cell physiology of the brain endothelium.

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    Advances in experimental medicine and biology
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The BBB is a dynamic interface between blood and the central nervous system enabling the brain to keep an optimal internal environment and manipulation of the BBB to allow entry of therapeutic agents may be justified under certain circumstances but should be done with caution.

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