Barrett oesophagus: lessons on its origins from the lesion itself

  title={Barrett oesophagus: lessons on its origins from the lesion itself},
  author={Stuart A. C. McDonald and Danielle L. Lavery and Nicholas Anthony Wright and M. J. H. Jansen},
  journal={Nature Reviews Gastroenterology &Hepatology},
Barrett oesophagus develops when the lower oesophageal squamous epithelium is replaced with columnar epithelium, which shows both intestinal and gastric differentiation. No consensus has been reached on the origin of Barrett oesophagus. Theories include a direct origin from the oesophageal-stratified squamous epithelium, or by proximal migration of the gastric cardiac epithelium with subsequent intestinalization. Variations of this theory suggest the origin is a distinctive cell at the… CONTINUE READING
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