Barrett oesophagus: lessons on its origins from the lesion itself

@article{McDonald2015BarrettOL,
  title={Barrett oesophagus: lessons on its origins from the lesion itself},
  author={Stuart A. C. McDonald and Danielle L. Lavery and Nicholas Anthony Wright and M. J. H. Jansen},
  journal={Nature Reviews Gastroenterology &Hepatology},
  year={2015},
  volume={12},
  pages={50-60}
}
Barrett oesophagus develops when the lower oesophageal squamous epithelium is replaced with columnar epithelium, which shows both intestinal and gastric differentiation. No consensus has been reached on the origin of Barrett oesophagus. Theories include a direct origin from the oesophageal-stratified squamous epithelium, or by proximal migration of the gastric cardiac epithelium with subsequent intestinalization. Variations of this theory suggest the origin is a distinctive cell at the… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 42 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Evolution of Premalignant Disease.

Cold Spring Harbor perspectives in medicine • 2017
View 2 Excerpts

Genomics, Endoscopy, and Control of Gastroesophageal Cancers: A Perspective

Cellular and molecular gastroenterology and hepatology • 2017

References

Publications referenced by this paper.
Showing 1-10 of 195 references

Columnar metaplasia in the esophageal remnant after esophagectomy: a systematic review.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus • 2015

Genome sequencing of normal cells reveals developmental lineages and mutational processes

S Behjati
Nature 513, • 2014

a study in an Asian population

Srivastava, S. et al. Immunohistochemical analysis of metaplastic oesophagus
Dig. Liver Dis. 46, 170–175 • 2014

data from a prospective Central European multicenter study (histoGERD trial)

Langner, C. et al. Multilayered epithelium at the gastroesopha disease
Virchows Arch. 464, 409–417 • 2014

Similar Papers

Loading similar papers…