Barr Virus Infection Abrogates the Stimulatory Capacity of Β Cells to a Major Histocompatibility Complex Class-II-Restricted Proliferative T-Cell Clone

@inproceedings{Lochern2005BarrVI,
  title={Barr Virus Infection Abrogates the Stimulatory Capacity of Β Cells to a Major Histocompatibility Complex Class-II-Restricted Proliferative T-Cell Clone},
  author={Ellen G. van Lochern and Astrid D. Bakker and Simone Snijder and Mijntje Aarts and Gijsbert C. de Gast and Eis Goulmy},
  year={2005}
}
After BMT, donor Τ cells are acnvated which can display GvHD as well as GvL activities In order to study this GvL-specifk T-cell response in vitro, proliferative T-cell ebnes from post-BMT PBMCs were generated by Stimulation with a patient's leukemic cells One C D 4 + T-cell clone (designaced M-33) displayed strong proliferative activity against the patient's leukemic cells but not against the patienc's EBV-LCLs The mduction of proliferation, however, appeared not to be leukemia specific… CONTINUE READING

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