Baroreflex and atrial natriuretic factor concentration correlate with myocardial infarct size and predict early death in rabbits: implications for drug studies.

@article{Hof1991BaroreflexAA,
  title={Baroreflex and atrial natriuretic factor concentration correlate with myocardial infarct size and predict early death in rabbits: implications for drug studies.},
  author={Robert Paul Hof and Yoshiharu Takiguchi and Juerg Nussberger and A. C. van Hof and Matthias P. Kl{\"a}y and Th. P. J. Peters and Robert Zelis and Hans Rudolf Alfred Brunner},
  journal={Journal of cardiovascular pharmacology},
  year={1991},
  volume={18 3},
  pages={
          361-8
        }
}
The severity of myocardial infarction (MI) and its functional consequences are difficult to assess in small animals. We searched for criteria to achieve such an assessment in rabbits 1 week after MI. Thirteen large mongrel rabbits (3-4 kg) were anesthetized with pentobarbitone for ligating a branch of the circumflex coronary artery and 7 rabbits were subject to a sham operation without ligation. All sham-operated rabbits and 12 MI animals survived for 1 week, when blood was obtained for… CONTINUE READING
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