Baroreceptor sensitivity of rat supraoptic vasopressin neurons involves noncholinergic neurons in the DBB.
@article{Grindstaff2000BaroreceptorSO,
title={Baroreceptor sensitivity of rat supraoptic vasopressin neurons involves noncholinergic neurons in the DBB.},
author={Ryan J Grindstaff and Regina R. Grindstaff and J. Thomas Cunningham},
journal={American journal of physiology. Regulatory, integrative and comparative physiology},
year={2000},
volume={279 5},
pages={
R1934-43
}
}Previous studies suggest that cholinergic neurons in the diagonal band of Broca (DBB) participate in the baroreceptor-mediated inhibition of phasic vasopressin neurons in the supraoptic nucleus (SON). To test this hypothesis, extracellular recordings were obtained from putative vasopressin SON neurons of anesthetized rats injected with the cholinergic immunotoxin 192 IgG-saporin (0.8 microg/microl) in the DBB. Baroreceptor sensitivity of neurons was tested with brief phenylephrine-induced (10…
12 Citations
A switch from GABA inhibition to excitation of vasopressin neurones exacerbates the development of angiotensin II‐dependent hypertension
- Biology, MedicineJournal of neuroendocrinology
- 2017
It is suggested that vasopressin exacerbates the increase in blood pressure evident early in the development hypertension and that blunted baroreflex inhibition of vasoppressin neurones is underpinned by an excitatory shift in their response to endogenous GABA signalling.
Physiological Regulation of Magnocellular Neurosecretory Cell Activity: Integration of Intrinsic, Local and Afferent Mechanisms
- Biology, MedicineJournal of neuroendocrinology
- 2013
An overview of recent advances in understanding of how intrinsic and local extrinsic mechanisms integrate with afferent inputs to generate appropriate physiological regulation of oxytocin and vasopressin MNC activity is provided.
Effects of Salt Loading on the Regulation of Rat Hypothalamic Magnocellular Neurosecretory Cells by Ionotropic GABA and Glycine Receptors
- BiologyJournal of neuroendocrinology
- 2016
This review highlights the various ways by which the two types of inhibitory receptors contribute to homeostasis by fine‐tuning the spiking rate of vasopressin‐releasing magnocellular neurosecretory cells in a manner dependent on the hydration state of the animal.
Magnocellular Neurons and Posterior Pituitary Function.
- Biology, MedicineComprehensive Physiology
- 2016
This review focuses on the control of magnocellular neuron activity with a particular emphasis on their regulation by reproductive function, body fluid balance, and cardiovascular status.
Dehydration followed by sham rehydration contributes to reduced neuronal activation in vasopressinergic supraoptic neurons after water deprivation.
- BiologyAmerican journal of physiology. Regulatory, integrative and comparative physiology
- 2010
Preabsorptive reflexes contribute to the regulation of AVP neurons in a manner independent of c-Fos expression in the lamina terminalis, and this reflex pathway may include inhibitory interneurons in the PNZ region surrounding the SON.
Time course analysis of tyrosine hydroxylase and angiotensinogen mRNA expression in central nervous system of rats submitted to experimental hypertension
- BiologyNeuroscience Research
- 2006
Activation of Different Neuronal Phenotypes in the Rat Brain Induced by Liver Ischemia–Reperfusion Injury: Dual Fos/Neuropeptide Immunohistochemistry
- BiologyCellular and Molecular Neurobiology
- 2010
The results show that both models of the LIRI activate, almost by the same effectiveness, a number of different neuronal phenotypes which stimulation may be associated with a complex of physiological responses induced by surgery, hemodynamic changes, and glucoprivation induced by fasting.
Baroreceptor reflex function.
- Biology, MedicineAmerican journal of physiology. Regulatory, integrative and comparative physiology
- 2002
The importance of the baroreceptor reflex is to stabilize perfusion pressure in the face of disturbances of circulatory homeostasis, and a number of neuronal and humoral regulatory adjustments are achieved.
Neurohumoral regulation of arterial pressure in hemorrhage and heart failure.
- MedicineAmerican journal of physiology. Regulatory, integrative and comparative physiology
- 2002
In both heart failure andhemorrhage, neurohormonal mechanisms are evoked in an attempt to restore arterial pressure to normal levels, but the relative importance of the various neuroh hormonal mechanisms in both conditions is unclear.
References
SHOWING 1-10 OF 40 REFERENCES
Catecholamine depletion of the diagonal band reduces baroreflex inhibition of supraoptic neurons.
- BiologyThe American journal of physiology
- 1992
The noradrenergic innervation of DBB appears to participate in the baroreceptor sensitivity of SON vasopressinergic neurons, and the norepinephrine content of the DBB was significantly reduced.
Ibotenate Lesions of the Diagonal Band of Broca Attenuate Baroreceptor Sensitivity of Rat Supraoptic Vasopressin Neurons
- BiologyJournal of neuroendocrinology
- 1992
The hypothesis that diagonal band of Broca neurons participate in a central pathway mediating the inhibitory effects of peripheral baroreceptor stimulation on the activity of vasopressin‐secreting neurons in the rat supraoptic nucleus is supported.
Perinuclear zone and diagonal band lesions enhance angiotensin responses of rat supraoptic neurons.
- BiologyThe American journal of physiology
- 1994
Ibotenate lesions of the DBB and the lateral hypothalamus that include the PNZ affect the ANG II-induced activation of putative vasopressin SON neurons in a manner consistent with results obtained from baroreceptor-denervated rats.
Immunoreactivity to vasopressin- but not oxytocin-associated neurophysin antiserum in phasic neurons of rat hypothalamic paraventricular nucleus
- BiologyBrain Research
- 1986
Lateral hypothalamic lesions alter baroreceptor‐evoked inhibition of rat supraoptic vasopressin neurones.
- BiologyThe Journal of physiology
- 1993
1. Previous electrophysiological studies on rat hypothalamic supraoptic nucleus neurones have demonstrated that both the activation of peripheral baroreceptors (induced by a brief rise in arterial…
Electrophysiology of excitatory and inhibitory afferents to rat histaminergic tuberomammillary nucleus neurons from hypothalamic and forebrain sites
- BiologyBrain Research
- 1997
Electrophysiological evidence that noradrenergic afferents selectively facilitate the activity of supraoptic vasopressin neurons
- BiologyBrain Research
- 1984
Loss of nucleus basalis magnocellularis, but not septal, cholinergic neurons correlates with passive avoidance impairment in rats treated with 192-saporin
- Biology, PsychologyNeuroscience Letters
- 1996
Diagonal band projection towards the hypothalamic supraoptic nucleus: Light and electron microscopic observations in the rat
- BiologyThe Journal of comparative neurology
- 1989
It is proposed that interneurons in the perinuclear zone serve as a relay station for information transfer from the ventral diagonal band to the SON, where GABAergic axon terminals are abundant and few GABAergic terminals contained HRP.







