Barium and strontium as calcium substitutes for contractile responses in the rat tail artery.

@article{Ebeigbe1985BariumAS,
  title={Barium and strontium as calcium substitutes for contractile responses in the rat tail artery.},
  author={Anthony B. Ebeigbe and Chukwuemeka Peter Aloamaka},
  journal={Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology},
  year={1985},
  volume={82 1},
  pages={
          213-6
        }
}
  • A. Ebeigbe, C. P. Aloamaka
  • Published 1985
  • Biology
  • Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
Extracellular magnesium and contractile responses to noradrenaline in the rat tail artery.
  • A. Ebeigbe, C. P. Aloamaka
  • Biology
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
  • 1986
Mechanism of contractile action of barium ion on rat aortic smooth muscle.
TLDR
The results suggest that Ba2+ ions enter rat aortic smooth muscle cells throughCa2+ channels and mobilize a noradrenaline-insensitive intracellular Ca2+ pool and may also cause a desensitization of some intrACEllular process.
Barium and strontium can substitute for calcium in stimulating nitric oxide production in the endothelium of canine coronary arteries.
TLDR
The present study suggests that Ba2+ and Sr2+ can substitute for Ca2+ in the activation of the NO synthase pathway in the endothelium of canine coronary arteries.
Role of endothelium in magnesium-induced relaxation of rat aorta
  • A. Ebeigbe, C. P. Aloamaka
  • Biology, Medicine
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
  • 1987
TLDR
The results suggest that Mg2+-induced relaxation of rat aorta is associated, at least in part, with the release of an endothelium-derived relaxant factor in receptor-mediated, but not in depolarisation-dependent contractions.
Signaling mechanisms for the selective vasoconstrictor effect of norbormide on the rat small arteries.
TLDR
The results suggest that NRB elicits its tissue and species-selective vasoconstrictor effect by stimulating PLC-PKC pathway and increasing Ca2+ influx through both verapamil-sensitive and -insensitive calcium channels.
Direct activation of endothelial NO pathway by Ba2+ in canine coronary artery
TLDR
The results suggest that the Ba2+‐induced relaxation is due to its direct activation of endothelial NO synthesis without mobilization of intracellular Ca2+.
Influence of Nanosilver on Endothelial Function and Vascular Reactivity of Isolated Rabbit Carotid Artery.
  • O. Uche, V. O. Ehanire
  • Medicine
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria
  • 2018
TLDR
Nanosilver causes attenuation in carotid arterial smooth muscle reactivity with a biphasic dose-dependentrelaxant effect and multiple endothelium-dependent pathways mode of action.
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References

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Strontium and barium as Substitutes for calcium on electrical and mechanical activity in rat portal vein.
TLDR
The mechanical responses to Sr and Ba appear to be combined effects of liberation of tissue Ca and direct action on the contractile system, which can explain the different concentration-effect curves obtained for the three ions with regard to integrated isometric force.
Stimulatory effects of Ba2+ on contractile activity in the smooth muscle of the rat portal vein.
TLDR
Ba2+ acts as a constrictor of the smooth muscle in rat portal vein partly by initiating an increased spike discharge, and partly by increasing the entry or release of Ca2+ per spike, whereas the removal of Ca1+ is unaffected.
Mechanism of action of barium ion on rat aortic smooth muscle.
TLDR
Findings indicate that barium produces its contractile effect on vascular smooth muscle by a direct intracellular interaction with the contractile or regulatory proteins in a physiologically releasable pool.
Mechanism of membrane stabilization by calcium in vascular smooth muscle.
TLDR
It is concluded that the relaxation produced by high concentrations of calcium is dependent on the activity of sodium-potassium ATPase; that produced by manganese is not; both are attenuated by ouabain, low sodium, reduced temperature, and low potassium.
D-600 and the membrane stabilizing effect of calcium in vascular smooth muscle.
  • R. Webb
  • Biology, Medicine
    Pharmacology
  • 1982
TLDR
D-600 blocks the transmembrane movement of calcium and interferes with membrane sites which mediate the stabilizing effect of this cation in isolated strips of rat tail artery, demonstrating that it antagonizes the membrane stabilizing influence of calcium.
Effect on the Guinea-pig Taenia Coli of the Substitution of Strontium or Barium Ions for Calcium Ions
TLDR
It is suggested that in the smooth muscle of taenia the membrane current during the action potential is carried principally by calcium ions, which would explain earlier findings that spike generation continues in solutions which are deficient in or free from sodium and that spike height is almost independent of the external concentration of sodium ions.
CALCIUM‐BINDING PHOSPHOPROTEIN OF PIG BRAIN: EFFECTS OF CATIONS ON THE CALCIUM BINDING
TLDR
The effects of various cations on the calcium‐binding properties of a brain phosphoprotein have been investigated employing an ultrafiltration binding assay and a postulated role for the protein as a calcium‐receptor molecule involved in release of neurotransmitters is discussed.
Vascular Smooth Muscle: Dual Effect of Calcium
TLDR
Observations suggest that the rate-limiting factor for the contractile response of rabbit aorta to epinephrine is membrane excitability (depressed by increased calcium), while that for the latter is the role that calcium plays in coupling membrane excitation with the development of tension by thecontractile protein.
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