Bardoxolone: augmenting the Yin in chronic kidney disease.

  title={Bardoxolone: augmenting the Yin in chronic kidney disease.},
  author={Merlin C Thomas},
  journal={Diabetes & vascular disease research},
  volume={8 4},
Nrf-2 (NF-E2-related factor 2) is a regulator of anti-oxidant, anti-inflammatory and detoxification pathways. Coordinated augmentation of these key defence pathways via Nrf-2 signalling is being investigated for the treatment of chronic diseases, including diabetes and its complications. The first to reach commercial development is the triterpenoid… CONTINUE READING