Barbiturate tolerance: effects on GABA-operated chloride channel function

@article{Allan1992BarbiturateTE,
  title={Barbiturate tolerance: effects on GABA-operated chloride channel function},
  author={Andrea M. Allan and Xiaoying Zhang and Lisa D. Baier},
  journal={Brain Research},
  year={1992},
  volume={588},
  pages={255-260}
}
Chronic pentobarbital administration alters γ‐aminobutyric acidA receptor α6‐subunit mRNA levels and diazepam‐insensitive [3H]Ro15‐4513 binding
TLDR
Data suggest that chronic pentobarbital treatment induced expression of α6‐subunit mRNA, a major component of the diazepam‐insensitive [3H]Ro15‐4513 binding site, which implied de novo synthesis of the receptor subunit protein.
Pressure-sensitive and -insensitive coupling in γ-aminobutyric acida receptors
Abstract. Rationale: Previous behavioral and biochemical studies suggest that allosteric coupling processes initiated by benzodiazepines, barbiturates and neuroactive steroids can be sub-categorized
Ethanol increases GABAA responses in cells stably transfected with receptor subunits.
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Analysis of data obtained from individual cells expressing alpha 1 beta 1-gamma 2L subunits showed considerable variability in sensitivity to ethanol, particularly with concentrations of 30 and 100 mM, suggesting the existence of ethanol-sensitive and -resistant receptors that may differ in subunit composition.
Use-dependent regulation of GABAA receptors.
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