Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype.

@article{Herrlin1998BantuTH,
  title={Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype.},
  author={Karin Herrlin and Amos Y Massele and Mary B. Jande and Christina Alm and Gunnel Tybring and Yakoub Aden Abdi and Agneta Wennerholm and Inger Johansson and Marja Liisa Dahl and Leif Bertilsson and Lars L. Gustafsson},
  journal={Clinical pharmacology and therapeutics},
  year={1998},
  volume={64 4},
  pages={391-401}
}
OBJECTIVE To investigate the CYP2C19 polymorphism in Tanzanians because this enzyme shows large interindividual differences in activity and metabolizes several drugs of importance in Africa, especially the antimalarial agent chloroguanide (INN, proguanil). METHODS Two hundred fifty-one Tanzanian healthy volunteers were phenotyped with respect to CYP2C19 with use of a single oral dose of mephenytoin (n = 106), a single oral dose of omeprazole (n = 207), or both. Sixty-two were phenotyped with… CONTINUE READING

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