Band 3, the anion exchanger of the erythrocyte membrane, is also a flippase.

@article{Ortwein1994Band3T,
  title={Band 3, the anion exchanger of the erythrocyte membrane, is also a flippase.},
  author={R Ortwein and A Oslender-Kohnen and B. Deuticke},
  journal={Biochimica et biophysica acta},
  year={1994},
  volume={1191 2},
  pages={317-23}
}
The transbilayer reorientation (flip-flop) of the long-chain amphiphilic anion DENSA (5-(N-decyl)aminonaphthalene-2-sulfonic acid) in the erythrocyte membrane was studied by fluorescence spectroscopy. DENSA intercalates into the membrane at a high membrane/water partition coefficient (3.2.10(5)) and rapidly reorients from the outer to the inner layer in a first order process (k = 0.11 min-1, 37 degrees C, pH 7.4) leading to a steady-state distribution inner:outer layer of about 30:70. The… CONTINUE READING