Ballooned neurones in the limbic lobe are associated with Alzheimer type pathology and lack diagnostic specificity.

@article{Fujino2004BalloonedNI,
  title={Ballooned neurones in the limbic lobe are associated with Alzheimer type pathology and lack diagnostic specificity.},
  author={Yasuhiro Fujino and Michael W Delucia and Peter Davies and Dennis W. Dickson},
  journal={Neuropathology and applied neurobiology},
  year={2004},
  volume={30 6},
  pages={676-82}
}
Ballooned neurones (BNs) are one of the pathological hallmarks of several neurodegenerative diseases, including Pick's disease, corticobasal degeneration and argyrophilic grain disease (AGD). They have also been described in Alzheimer disease (AD), but the frequency of BNs in AD has not been systematically addressed. In the present study, immunohistochemistry for alphaB-crystallin was used as a sensitive method to detect BNs to determine the frequency of BNs in the limbic lobe in AD. At least a… CONTINUE READING
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