Balancing the immune system for tolerance: a case for regulatory CD4 cells.

@article{Field1997BalancingTI,
  title={Balancing the immune system for tolerance: a case for regulatory CD4 cells.},
  author={Elizabeth H. Field and Qiangguo Gao and Neal X. Chen and Thomas M. Rouse},
  journal={Transplantation},
  year={1997},
  volume={64 1},
  pages={
          1-7
        }
}
In the past, tolerance mechanisms have focused on processes that involve elimination (deletion) or paralysis (anergy) of immune responses. It is now becoming clearer that peripheral tolerance to antigen depends on the generation of regulatory cells that function to maintain the tolerant state. The development of peripheral tolerance may require that the immune system utilize several strategies, including deletion, anergy, and immunoregulatory pathways, and these strategies may overlap. Recent… CONTINUE READING
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