Balancing speed and accuracy of polyclonal T cell activation: a role for extracellular feedback

@inproceedings{Savir2012BalancingSA,
  title={Balancing speed and accuracy of polyclonal T cell activation: a role for extracellular feedback},
  author={Yonatan Savir and Nir Waysbort and Yaron E. Antebi and Tsvi Tlusty and Nir Friedman},
  booktitle={BMC Systems Biology},
  year={2012}
}
Extracellular feedback is an abundant module of intercellular communication networks, yet a detailed understanding of its role is still lacking. Here, we study interactions between polyclonal activated T cells that are mediated by IL-2 extracellular feedback as a model system. Using mathematical modeling we show that extracellular feedback can give rise to opposite outcomes: competition or cooperation between interacting T cells, depending on their relative levels of activation. Furthermore… CONTINUE READING