Balancing prostanoid activity in the human vascular system.

@article{Flavahan2007BalancingPA,
  title={Balancing prostanoid activity in the human vascular system.},
  author={N. Flavahan},
  journal={Trends in pharmacological sciences},
  year={2007},
  volume={28 3},
  pages={
          106-10
        }
}
  • N. Flavahan
  • Published 2007
  • Biology, Medicine
  • Trends in pharmacological sciences
The imbalance theory proposes that arterial thrombosis is dependent on a ratio or balance between the cyclooxygenase (COX)-1-dependent generation of thromboxane in platelets and the COX-2-dependent generation of prostacyclin in the endothelium. Accordingly, by reducing endothelium-derived prostacyclin levels, selective COX-2 inhibitors would increase susceptibility to vasoconstriction, platelet activation and atherothrombosis. This imbalance theory has been frequently used to legitimize the… Expand
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In this article I describe some of my work over the past 50 years, and hope to show that it is not only Princes who travel the road to Serendip but also Scientists. Expand
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